T… They are based predominantly on reports following some epidemics of mass poisonings, which may underestimate toxicity. Based on a work at https://litfl.com. 314.36 Molecular Formula. This category only includes cookies that ensures basic functionalities and security features of the website. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. In the liver, diethylene glycol is metabolized into 2-hydroxyethoxyacetic acid (aka HEAA) which is known to contribute to the renal and neurological damage that is characteristic of poisoning (Minns, 2012)(Schep et al., 2009)(Brent, 2001). Diethylene glycol (DEG) Diethylene glycol What is it? 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 04/23/2018 Revision date: 04/23/2018 Supersedes: 10/20/2015 Version: 1.2 Controversies in the Management of Functional Constipation in Children. Diethylene glycol (DEG) is a clear, colorless, practically odorless, viscous, hygroscopic liquid with a sweetish taste. This site uses Akismet to reduce spam. He is an internationally recognised Clinician Educator with a passion for helping clinicians learn and for improving the clinical performance of individuals and collectives. Researchers have implicated the chemical in multiple medication-associated mass poisonings over the years, according to Joshua G. Schier and fellow researchers from the Centers for Disease Control and Prevention. Slaughter RJ, Mason RW, Beasley DM, Vale JA, Schep LJ. Related Pages. Metabolism occurs principally in the liver and both the parent and the metabolite, 2-hydroxyethoxyacetic acid (HEAA), are renally eliminated rapidly. McKenzie BA, Robles-Najar J, Duong E, Brisk P, Grover WH. >1 mL/kg or a mouthful in a child is potentially lethal ethylene glycol itself is relatively non-toxic -> metabolites extremely toxic (glycolate) rate limiting step = alcohol dehydrogenase activity accumulation of glycolate -> direct cellular toxicity Characterizing concentrations of diethylene glycol and suspected metabolites in human serum, urine, and cerebrospinal fluid samples from the Panama DEG mass poisoning. Propylene glycol toxicity is metabolized to compounds that are normal constituents of the citric acid cycle. All EGs exert acute toxicity in a similar manner, characterized by CNS depression and metabolic acidosis in humans and rodents; the larger molecules being proportionally less acutely toxic on a strict mg/kg basis. C 1 8 H 1 8 O 5. Ethylene glycol poisoning is poisoning caused by drinking ethylene glycol.  |  TOXICITY OF DEG: Doses of DEG necessary to cause human morbidity and mortality are not well established. Later symptoms may include a decreased level of consciousness, headache, and seizures. Conclusions: NIH Prognosis may be improved, however, with prompt supportive care and timely use of fomepizole or ethanol. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. But more than 100 people died after taking the drug, and investigators from the US Food and Drug Administration (FDA) identified the drug’s solvent, diethylene glycol, as the killer. Clipboard, Search History, and several other advanced features are temporarily unavailable. He has completed fellowship training in both intensive care medicine and emergency medicine, as well as post-graduate training in biochemistry, clinical toxicology, clinical epidemiology, and health professional education. Chronoprints: Identifying Samples by Visualizing How They Change over Space and Time. Quality of fixed dose artemether/lumefantrine products in Jimma Zone, Ethiopia. If patients are stabilized, they may then enter the final phase with various delayed neuropathies and other neurological effects, sometimes fatal. In addition to its use in a wide range of industrial products, it has also been involved in a number of prominent mass poisonings spanning back to 1937. Inhibition of metabolism of diethylene glycol prevents target organ toxicity in rats. Updated. Epub 2014 May 9. Diethylene glycol was found to be of low toxicity (BG Chemie 1989b). 2-Propenoic acid, 2-(2-hydroxyethoxy)ethyl ester Clin Toxicol (Phila). Please enable it to take advantage of the complete set of features! Toxicokinetics: More often, these epidemics have occurred in developing and impoverished nations where there is limited access to intensive medical care and quality control procedures are substandard. Despite the discovery of DEG’s toxicity in 1937 and its involvement in mass poisonings around the world, the information available regarding human toxicity is limited. He is one of the founders of the FOAM movement (Free Open-Access Medical education) and is co-creator of litfl.com, the RAGE podcast, the Resuscitology course, and the SMACC conference. Epub 2011 Jul 29. 3.1O acute toxicity (oral) 4 Acute Tox. In July 2007 the Spanish authorities informed the Commission services about their findings Diethylene Glycol is an aliphatic diol. In case of sale of your personal information, you may opt out by using the link. 4 H302 3.9 specific target organ toxicity - repeated exposure 2 STOT RE 2 H373 The most important adverse physicochemical, human health and environmental effects Safety Data Sheet acc. FDA HISTORY OFFICE T he US Food and Drug Administration’s role in the … -> ethanol dose (IV): 10% solution in D5W as a 40% solution, loading dose 7.5mL/kg -> 1-2mL/kg/hr-> ethanol dose (PO): quarter the above dose-> dose in CRRT: double IV dose-> maintain ethanol level @ 25-40mmol/L. … Welcome to PubChem! He coordinates the Alfred ICU’s education and simulation programmes and runs the unit’s education website, INTENSIVE. These cookies do not store any personal information. Testing Status of Diethylene glycol 10993-P . Acute Toxicity Data and References. Management: Toxicol Sci. He created the ‘Critically Ill Airway’ course and teaches on numerous courses around the world. EG is rapidly absorbed from the GI tract; in dogs, blood concentrations of EG peak within 3 hr of ingestion. Introduction: Despite DEG's toxicity and associated epidemics of fatal poisonings, a comprehensive review has not been published. Long term outcomes may include kidney failure and brain damage. We also use third-party cookies that help us analyze and understand how you use this website. Role of tissue metabolite accumulation in the renal toxicity of diethylene glycol. 2013 Dec;51(10):923-9. doi: 10.3109/15563650.2013.850504. Introduction: Diethylene glycol (DEG) is a clear, colorless, practically odorless, viscous, hygroscopic liquid with a sweetish taste. Clinical Adjunct Associate Professor at Monash University, Australia and New Zealand Clinician Educator Network, Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, >1 mL/kg or a mouthful in a child is potentially lethal, ethylene glycol itself is relatively non-toxic -> metabolites extremely toxic (glycolate), rate limiting step = alcohol dehydrogenase activity, accumulation of glycolate -> direct cellular toxicity. For guinea pigs the oral LD 50 was 7.76 ml/kg body weight (about 8700 mg/kg body weight) and for rabbits … Laboratory findings in clinical assessment of diethylene glycol can include an elevated osmolar gap, elevated anion gap, elevated creatinine, and acidosis [8,11,12] . He is a co-founder of the Australia and New Zealand Clinician Educator Network (ANZCEN) and is the Lead for the ANZCEN Clinician Educator Incubator programme. After finishing his medical degree at the University of Auckland, he continued post-graduate training in New Zealand as well as Australia’s Northern Territory, Perth and Melbourne. He is on the Board of Directors for the Intensive Care Foundation and is a First Part Examiner for the College of Intensive Care Medicine. Absorption Disposition Metabolism Elimination (Dosed-Water; Gavage; Intravenous) (S0219) Completed . Epidemiology: U.S. Federal Regulations TSCA 12(b) Not applicable SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA Occupational Safety and Health Administration 2019 Jul 15;18(1):236. doi: 10.1186/s12936-019-2872-1. COVID-19 is an emerging, rapidly evolving situation. Diethylene Glycol-d8 | C4H10O3 | CID 71309368 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. 2019 Dec;15(4):649-652. doi: 10.1007/s12024-019-00123-4. Clin Toxicol (Phila). Besenhofer LM, Adegboyega PA, Bartels M, Filary MJ, Perala AW, McLaren MC, McMartin KE. This site needs JavaScript to work properly.  |  This website uses cookies to improve your experience while you navigate through the website.  |  | INTENSIVE | RAGE | Resuscitology | SMACC. We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. DEG is used as a component of multiple different products including antifreeze preparations, cosmetics, lubricants, brake fluids, wallpaper strippers, heating/cooling fuel and as a plasticizer. Early symptoms include intoxication, vomiting and abdominal pain. Diethylene glycol (DEG) is an organic compound with the formula (HOCH2CH2)2O. You also have the option to opt-out of these cookies. 111-46-6 - MTHSVFCYNBDYFN-UHFFFAOYSA-N - Diethylene glycol - Similar structures search, synonyms, formulas, resource links, and other chemical information. Initial treatment consists of appropriate airway management and attention to acid-base abnormalities. These cookies will be stored in your browser only with your consent. Analytical cookies are used to understand how visitors interact with the website. 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