Skin corrosion/irritation - Category 4. Long-term exposure can result in thickening of the skin, darker skin, abdominal pain, diarrhea, heart disease, numbness, and cancer. Acute toxicity (Dermal) - Category 4. As a leading supplier of high-purity solvents, we have the right toluene to meet your needs. Pulmonary aspiration may cause a hydrocarbon pneumonitis (See Hydrocarbons). If arsenic poisoning occurs over a brief period of time, symptoms may include vomiting, abdominal pain, encephalopathy, and watery diarrhea that contains blood. Specific target organ toxicity - Single exposure - Category 1B. 1.1. Immunotoxicity data are available but the results are conflicting. This leads to the con- cept of « dispensable tissues, » substance that in straighten out to achieve tumor eradication, it was demanded to keep in view tissue-specific toxicity damaging general tissues [59]. for metabolites been ascertained in the toxicity of toluene. 108-88-3) In Support of Summary Information on the Integrated Risk Information System (IRIS) September 2005 U.S. Environmental Protection Agency Washington D.C. DISCLAIMER This document has been reviewed in accordance with U. S. Environmental Protection Agency policy and approved for publication. It has been suggested that toluene interferes with the normal function of neuronal proteins. Background: Toluene is one of the most widely abused inhaled drugs due to its acute neurologic effects including euphoria and subsequent depression. They may include muscle weakness, poor coordination, numbness in the hands and feet, skin rashes, anxiety, memory problems, trouble speaking, trouble hearing, or trouble seeing. Five motile strains of bacteria that use five different pathways to degrade toluene were tested for their ability to detect and swim towards this pollutant. This article is for information only. They are mild mucous membrane irritants that affect the eyes and the respiratory and GI tracts. White matter T2 hyperintensity (focal and diffuse) is the most common finding, seen in approximately 50% of patients, typically after at least 4 years of abuse. Product form : Substance Substance name : Toluene CAS-No. Respiratory sensitization - Category 2A-2B. According to OSHA, it’s often used in a mixture with other solvents and chemicals, such as paint pigments, so employees who work with paint, metal cleaners and adhesives may be at risk for exposure. Use restrictions (high), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (high), Ecotoxicology (low), Irritation (skin, eyes, or lungs) (high), and Contamination concerns (high) antioxidant and solvent. Toluene-3,4-dithiol | C7H8S2 | CID 10334 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. The exposure may also be through direct skin and eye contact, or upon inhaling the vapors; This intake could be accidental, or in some cases intentional, to bring self-harm; Toluene is a poisonous liquid that is highly flammable ; Note: The … Toluene TWA 20 ppm US. Like other aromatic hydrocarbons, they may sensitize the myocardium to the arrythmogenic effects of catecholamines. The bodies of cult members of the People’s Temple, in. The key to managing cyanide toxicity is patient education. Toluene and xylene are strong compounds that are used in many household and industrial products. The public should also … Toluene Poisoning is caused by the ingestion of toluene (liquid). Mechanism of toxicity. MRI is the modality of choice for evaluation of cerebral changes related to toluene toxicity. Acute Toxicity: Dermal: 108-88-3 (Toluene) LD50 Rabbit: 12,124 mg/kg Oral: 108-88-3 (Toluene) LD50 Rat: 5000mg/kg Inhalation: 108-88-3 (Toluene) LC50 Rat: 12,500 - 28,800 mg/m3/4 h Chronic Toxicity: No additional information. Organ system toxicity: Dysfunction of the central nervous system following acute, intermediate or high inhalation exposure to toluene is a critical health concern. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. F igure 3.2. It was first isolated in 1837 from pine oil by Polish chemist Filip N. Walter. The toxicity assessment in terms of EC 50 value demonstrated that benzene was less toxic compared to the other BTEX compounds. Arsenic poisoning is a medical condition that occurs due to elevated levels of arsenic in the body. Each peer-reviewed profile identifies and reviews the key literature that describes a hazardous substance's toxicologic properties. Acute toxicity (Inhalation: Dusts and mists) - Category 2. TOLUENE (CAS No. High-level exposure to methylmercury is known as Minamata disease. Toluene, the main component of volatile glues, lacquer thinners and aerosol paints is the chemical responsible for most clinical toxicity. Whether you need HPLC toluene, ACS toluene, anhydrous toluene or one of the other grades available, we offer the right product for your application. The bioremediation of polluted groundwater and toxic waste sites requires that bacteria come into close physical contact with pollutants. DO NOT use it to treat or manage an actual poison exposure. Classic symptoms of arsine gas toxicity include headache, nausea, vomiting, diarrhea, "port wine" hued urine and jaundice. Low to moderate daily workplace exposure can cause temporary tiredness, confusion, weakness, nausea and memory loss. Identification . The effects are either from acute intoxication or from organ system dysfunction as a result of chronic and persistent abuse. BACKGROUND AND PURPOSE: Chronic abuse of toluene by inhalation causes variable white matter changes and thalamic hypointensity on T2-weighted MR images. IN cases of suspected arsenic exposure it is imperative to call 911 for immediate transfer to the nearest hospital. The Forensic Aspects of Poisons . SCCP agrees that important official reports have been issued recently on the toxicity profile and safety of toluene, and has considered the following (summary) documents: 3.1.1. 11,13,15,16 Absorption occurs from inhalation, ingestion, or transdermal exposure, and can be detected in blood within minutes. 77, No. It deprives cells of the ability to use oxygen. … 28. Healthcare workers that include nurses, pharmacists, and physicians need to educate the public about the dangers of cyanide in the workplace. Often toluene exposure occurs in conjunction with benzene and since they are to some degree metabolised by the same enzymes, the relative concentrations will determine their rate of elimination. CNS toxicity may be due to the liposolubility of toluene in the neuronal membrane. Inhalants cause an initial excitatory response OSHA Table Z-1-A (29 CFR 1910.1000), as amended MAX. Toluene Safety Data Sheet according to Federal Register / Vol. COVID-19 is an emerging, rapidly evolving situation. Mention of trade names or commercial products does not constitute … Cyanide can even be absorbed through the skin, hence people who work with cyanide-related chemicals must wear appropriate garments and protective inhalational devices. Chapter 5.14 Toluene General description Physical and chemical properties Toluene (C 6H 5CH 3) is a noncorrosive, volatile liquid with an aromatic odour. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 03/21/2014 Revision date: 02/27/2018 Supersedes: 03/21/2014 Version: 1.1 02/27/2018 EN (English) Page 1 SECTION 1: Identification . Health supervision visits forced to be viewed as business of a continuum of circumspection, not as the exploit of isolated tasks. The odour threshold varies considerably; a geometric mean of 11 ppm has been estimated from published data (2). The data to date are inadequate to draw conclusions regarding whether immunosuppression may be a more sensitive endpoint (i.e., an endpoint that would result in a lower point of departure) than kidney toxicity. When exposure to toluene occurs there is usually simultaneous exposure to several other chemicals. 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