We'd love your feedback! The recommendations in this article are for the Polyethylene Glycol 3350 Powder for solution is available in either pre-measured 17 gram packets or bulk powder such as MiraLax®, Dulcolax Balance®, and various generic names. Her practice incorporates herbal medicine, complementary therapies and environmental stewardship to help dogs and people find balance and partnership with nature.  Plumb’s Veterinary Handbook by Donald C. Plumb, 9th Edition. ©Copyright 1999 - 2020. Polyethylene glycol (PEG) 3350 is not. If you suspect your cat has symptoms of Heinz body, contact your veterinarian for testing and treatment. I know you would not give Myralax to your dog but you might unknowingly give PEG to them if you are not carefully reading labels. To find a holistic or homeopathic vet near you or to find one who will do phone consultations, visit The Academy Of Veterinary Homeopathy. Yes No. The National Institute for Occupational Safety and Health (www.cdc.gov/niosh) notes: “Ethylene glycol is chemically broken down in the body into toxic compounds. Sign up for the Dogs Naturally Newsletter and get over 200 FREE Health Plans and Guides in 2020. If you look at polyethylene glycol’s Material Safety Data Sheet (MSDS), under “Skin Contact” it reads: “Immediately flood affected skin with water while removing and isolating all contaminated clothing. It is widely used as an additive in pharmaceuticals, cosmetics and food . Recently, I was working with a dog who was suffering from severe itching and hair loss. Anaheim, CA, USA.  It is also not approved for breeding, nursing or lactating dogs or cats but is considered safe by many veterinarians. How to use Polyethylene Glycol 3350 17 Gram/Dose Oral Powder. Carr A, Gaunt M. Constipation resolution with the administration of polyethylene-glycol solution in cats. In: 80th Annual Western Veterinary Conference Notes (WVC 2008). Rita combines nature with her love for dogs by offering consulting that focuses on dogs as individuals: mind, body and spirit. The Cosmetic Ingredient Review board (CIR) studies chemical compounds found in cosmetics. Take by mouth usually once daily, or as directed by your doctor or the directions on the product package.. The International Agency for Research on Cancer (www.iarc.fr) has classified ethylene oxide as a known human carcinogen that can harm the nervous system and interfere with human development.   Medication should never be administered without first consulting your veterinarian. This quality makes the chemical extremely versatile as an additive to everything from antifreeze to food. Below 55°C it is a free flowing white powder freely soluble in water. Minneapolis, MN, USA; 2016. The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Polyethylene glycol functions as a “penetration enhancer,” which means it increases the permeability of the skin to allow the rapid absorption of substances through the skin layer. That’s why you must base the dog’s dose on their weight (rather than what the drug’s leaflet says). Webster R, Didier E, Harris P, et al. Seek medical attention if warranted.” Um, how can anyone think that rubbing PEG on any type of skin is a good idea after reading this warning? Consult with your veterinarian to determine if other drugs your pet is receiving could interact with Polyethylene glycol 3350. American Society of Hospital Pharmacists. No metabolism of PEG400 to ethylene glycol after oral administration to dogs and man could be demonstrated (determination of oxidizable substances in the plasma, Shaffer et al. After we went through the usual dietary factors, we started to go over her environment and eventually her grooming products. We recently showed how polyethylene glycol (PEG), a fusogen[1, 9] applied immediately on full transection of the spinal cord (so-called GEMINI protocol) can lead to motor recovery in mice, rats, and dogs. Ethylene glycol has a very narrow margin of safety – which means only a tiny amount can result in severe poisoning. This drug is not approved for use in animals by the Food and Drug Administration but it is prescribed legally by veterinarians as an extra-label drug. Propylene glycol (PG) is one of the least toxic glycols.. Cats are particularly sensitive to PG and its use is no longer allowed in cat foods. Polyethylene glycol moderately non-toxic and its absorption into the physique is less than 0.5%. Route of elimination. Some pets will appear to strain which can look like constipation but is actually. Polyethylene glycol. This is most commonly seen when pets ingest liquid, high concentration propylene glycol … Aspiration is an uncommon but potentially devastating complication of polyethylene glycol administration. 1,4-dioxane is a chemical that remains in the environment for long periods of time because it does not easily degrade. Polyethylene Glycol 3350 Powder for the solution is available in either pre-measured 17-gram packets or bulk powder such as MiraLax®, Dulcolax Balance®, and various generic products. Propylene glycol is also used to make polyester compounds, and as a base for de-icing solutions. When taken internally, PEG causes the colon to absorb water and produce a watery stool. Polyethylene glycol 3350 normally causes loose or even watery stools. The bigger GP issue is with cats. Do not use polyethylene glycol 3350 more than once per day. While generally safe and effective when prescribed by a veterinarian, Polyethylene glycol 3350 can cause side effects in some animals. She had just gotten spayed. Propylene glycol is a colorless, odorless synthetic liquid that absorbs water. PEG can accumulate in the body if it is able to penetrate the skin layer, affecting your dog’s skin and coat, nervous system, and beneficial bacteria. The content on this website is not meant to replace veterinary advice. Polyethylene glycol, more commonly known as PEG 400, is used as a plasticizer, surfactant, suppository base and ointment, solvent, and capsule and tablet lubricant in the pharmaceutical industry. mixture of bonded polymer plastic compounds that are combined with glycol to make a thick sticky liquid Following administration of an oral suspension containing 140 grams of PEG 3350 in healthy subjects, up to 85% to 99% of the compound was excreted in the feces. If you don’t know what something is, research it and find out if it is safe for you and your dog. It is also used to empty the intestines prior to diagnostic procedures. Her diet was perfect, her home environment was as non-toxic as you can get. Polyethylene glycol is a metabolically inert laxative that does not undergo intestinal enzymatic degradation or bacterial metabolism. PEG is non-toxic and has no effect on the body. But though it is considered generally safe for human and animal consumption, cats have a unique sensitivity to propylene glycol … Although less toxic than EG, ingestion of propylene glycol (PG) may be associated with a toxic syndrome similar to the acute phase of EG toxicosis. Polyethylene glycol (PEG) or macrogol is a polyether compound. The IHC Group. Call your doctor if you are still constipated or irregular after using this medication for 7 days in a row. Human formulations: There are several different trade name products for docusate. Different types of macrogol exist according to their molecular weight from 300 g/mol to 10,000,000 g/mol . Then, I came across a new wellness product she had been using that contained polyethylene glycol. Leib MS. Colonoscopy. It and its toxic by-products first affect the central nervous system, then the heart, and finally the kidneys. 5. In: AHFS drug information 2010. In cats, the dose of Polyethylene Glycol 3350 Powder for the solution most commonly used is as a laxative is 1/8 to ¼ teaspoon every 12 hours on food. Polyethylene glycol, otherwise known as PEG, is a mixture of bonded polymer plastic compounds that are combined with glycol to make a thick sticky liquid. Sounds healthy, right? Polyethylene Glycol 3350 (MiraLAX) for Dogs and Cats Posted by By Admin May 21, 2020 No Comments. Many animals will voluntarily drink ethylene glycol if antifreeze is spilled or leaks onto garage floors or driveways. J Feline Med Surg 2011. Dogs rely on these bacteria for a healthy immune system and a balanced pH level. Common names include Clearlax, Colyte, Dulcolax, Easylax, EZ2GO, Gavilax, Gavilyte, Gialax, Glycolax, Golytely, Healthylax, Laxaclear, Miralax, Moviprep, Natura-Lax, Nulytely, Pegylax, Powderlax, Purelax, Smooth lax, and Trilyte. Symptoms of Propylene Glycol Toxicity in Dogs. In cats, ingestion of a diet containing 6%–12% PG can result in Heinz body formation and decreased RBC survival. In dogs, the dose of Polyethylene Glycol 3350 Powder for solution varies with the size of the dog: Small dogs – 1/8 to ¼ teaspoon every 12 hours (twice daily), Medium sized dogs – ¼ to ½ teaspoon every 12 hours (twice daily), Large dogs – ½ to ¾ teaspoon every 12 hours (twice daily).  Tam FM, Carr AP, Myers SL. Propylene glycol is a synthetic liquid substance that absorbs water. The chemical formula is HO(C2H4O)nH in which n represents the average number of oxyethylene groups. Such drugs include certain other laxatives and stool softeners. 1950). The Food and Drug Administration (FDA) has classified propylene glycol as . The product my client was using was for her dog’s surgical wound. Tweet. Polyethylene glycol 3350 should produce a bowel movement within 1 to 3 days of using the medication. Bethesda, MD, USA: American Society of Health-System Pharmacists; 2010. Polyethylene glycol 3350. Safety and palatability of polyethylene glycol 3350 as an oral laxative in cats. Never exceed 3/4 teaspoon of Miralax for every 10 pounds of the dog’s body weight over a 24-hour period. & M. Gaunt (2010). [3, 7, 8, 10] In this paper, we present the histological evaluation of the fusion process in dogs. I encourage you to keep reading labels and looking up ingredients. All animals are susceptible to ethylene glycol (EG) toxicity, but it is most common in dogs and cats. If you need help, call us at 800.786.4751.-The Revival Education Team Was this helpful? Somehow, the chemical has worked its way into cosmetics, canine wellness products and medicine. Half-life. It is commonly used in humans before diagnostic procedures such as colonoscopy. As little as half a teaspoon per pound of a dog’s body weight can result in fatality. From the information that I found, it would not make sense for natural product and cosmetic manufacturers to use PEG and PEG derivatives but they do. You might be more familiar with a product called Myralax, which is sold as a laxative. In cats, ingestion of a diet containing 6%–12% PG can result in Heinz body formation and decreased RBC survival. Carr, A. MATERIALS AND METHODS Dogs may be attracted to ethylene glycol by its sweet taste. Propylene glycol is a synthetic food additive that belongs to the same chemical group as alcohol. However, according to Dr. Karen Becker, an integrative wellness veterinarian, propylene glycol can be toxic to dogs at certain levels. Ingestion of sufficient amounts can be fatal”. Propylene glycol is not as toxic as another common antifreeze ingredient known as ethylene glycol; however, it is still poisonous and dogs require medical treatment if ingested. PEG 3350 is an over-the-counter laxative sold using th… Experimentally, propylene glycol administration in dogs at 2 g/kg/day has caused no adverse effects. The oral LD 50 of PG in dogs is ~9 mL/kg. Another issue that polyethylene glycol has is contamination. It is also used to empty the intestines prior to diagnostic procedures. This warning is alarming for a topical product that directs you to rub it on damaged skin. Current Veterinary Therapy XV, Bonagura and Twedt. Polyethylene glycol (PEG; / ˌ p ɒ l i ˈ ɛ θ əl ˌ iː n ˈ ɡ l aɪ ˌ k ɒ l,-ˌ k ɔː l /) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine. The oral median lethal dose (LD50) of propylene glycol in dogs has been reported to be ~9 ml/kg body weight. 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